How a 2 meters long DNA is fitted into a 2 micrometers Nucleus?

An average Human cell (diploid) contains about 6.4 billion base pairs of DNA divided among 46 chromosomes. The length of each base pair is about 0.34 nm. Therefore, if the DNA molecule in a diploid cell were laid out end to end, the total length of DNA would be approximately 2 meters.Since the diameter of a typical cell nucleus is only 10 ΞΌm, it is obvious for us to know that how is it possible to fit 2 meters of DNA in such small space without getting tangled up. The answer lies in the remarkable manner in which a DNA molecule is packaged. […]